Thrombotic microangiopathy in juvenile dermatomyositis

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Thrombotic microangiopathy in juvenile dermatomyositis

Objectives and study A 4year-old boy was admitted to our hospital because of progressive proximal muscular weakness of 4 weeks duration, heliotrope rash, erythematous skin lesions in the trunk and limbs and febrile fever. The muscle enzymes were elevated: creatine kinase 7,056 IU/L (0– 170), aldolase 40.3 U/L (0–8), aspartate transaminase 601 U/L (10–37), alanine transaminase 289 U/L (10–37). T...

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A difficult case of juvenile dermatomyositis complicated by thrombotic microangiopathy and purtscher-like retinopathy

Results A 16 year old girl was admitted for fever, diffuse pain, asthenia, sore throat and generalised papular rash. Initial work-up showed leukopenia, elevation in creatine phosphokinase (CK) (650 U/l) and transaminase. Epstein-Barr Virus (EBV) serology was compatible with acute infection and the initial treatment was symptomatic. Subsequent deterioration of general conditions, progressive pol...

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HIV associated thrombotic microangiopathy.

Thrombotic microangiopathy (TMA) is a known complication of HIV infection. Endothelial cell injury appears to be the primary event causing platelet activation and deposition in the microvasculature. Direct cytopathic roles of HIV as well as other factors such as malignancy, drugs, and infectious agents have been implicated in the pathogenesis of HIV-TMA. Although the the majority of patients pr...

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Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare clinical entity where tumor cell embolisms in pulmonary circulation induce thrombotic microangiopathy (TMA), respiratory failure, and subacute cor pulmonale. We describe 3 cases of PTTM that presented as the initial manifestation of metastatic gastric adenocarcinoma with TMA and pulmonary infiltrates. All 3 cases had similar clinical a...

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Pregnancy Associated Thrombotic Microangiopathy

The thrombotic microangiopathies (TMA) are a group of common microvascular occlusive disorders characterized by thrombocytopenia, microangiopathic hemolysis and multiorgan dysfunction. The pathological features are vascular damage manifested by arteriolar and capillary thrombosis with characteristic abnormalities in the endothelium and vessel wall. Pregnancy associated TMA is a life threatening...

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ژورنال

عنوان ژورنال: Pediatric Rheumatology

سال: 2011

ISSN: 1546-0096

DOI: 10.1186/1546-0096-9-s1-p49